The Wild Toads – Developing New Strategies for a Green Future Using Boron Chemistry

Developing New Strategies for a Green Future Using Boron Chemistry

The Wild Toads is a research group at Mount Allison University focused on boron chemistry.

Research

The Phosphinoboration Reaction

Investigating the synthesis and reactivity of novel phosphinoborane species.

Kindervater, M. B.; Binder, J. F.; Baird, S. R.; Vogels, C. M.; Geier, S. J.; Macdonald, C. L. B.; Westcott, S. A.* J. Organomet. Chem. 2019, 880, 378-385. Geier, S. J.; LaFortune, J. H. W.; Zhu, D.; Kosnik, S. C.; Macdonald, C. L. B.; Stephan, D. W.;* Westcott, S. A.* Dalton Trans. 2017, 46, 10876-10885. Daley, E. N.; Decken, A.; Mellonie, N. R.; Doherty, S.;* Westcott, S. A.* Chem. Eur. J. 2017, 23, 14485-14499. Daley, E. N.; Vogels, C. M.; Geier, S. J.; Decken, A.; Doherty, S.;* Westcott, S. A.* Angew. Chem. Int. Ed. 2015, 54, 2121-2125.

New Rhodium Complexes

Lee, G. M.; Bowes, E. G.; Vogels, C. M.; Decken, A.; Westcott, S. A.* Tetrahedron 2019, 75, 2106-2112. Geier, M. J.; Geier, S. J.; Halcovitch, N. R.; Vogels, C. M.; Decken, A.; Westcott, S. A.* Polyhedron 2013, 52, 1181-1189. Geier, M. J.; Vogels, C. M.; Decken, A.; Westcott, S. A.* Eur. J. Inorg. Chem. 2010, 4602-4610.

Capsaicinoids

Developing new boron-containing natural product derivatives for enhanced bioactivities for potential pesticides, antibiotics, anticancer drugs, etc.

Ramsaywack, S.; Bos, A.; Vogels, C. M.; Gray, C. A.;* Westcott, S. A.* Can. J. Chem. 2018, 96, 1065-1070.

Anti-Cancer Compounds I

Coordination complexes of palladium and platinum as anticancer complexes.

Stewart, E. L.; Patterson, A. E.; O’Neill, T.; Li, H.; Flewelling, A.J.; Vogels, C. M.; Decken, A.; Lloyd, V. K.;* Gray, C. A.;* Westcott, S. A.* Can. J. Chem. 2013, 91, 131136. Conrad, M. L.; Enman, J. E.; Scales, S. J.; Zhang, H.; Vogels, C. M.; Saleh, M.; Decken, A.; Westcott, S. A.* Inorg. Chim. Acta. 2005, 358, 63-69.

Anti-Cancer Compounds II

Coordination complexes of palladium and platinum as anticancer complexes.

St-Coeur, P.-D.; Kinley, S.; Vogels, C. M.; Decken, A.; Morin, P. Jr.;* Westcott, S. A.* Can. J. Chem. 2017, 95, 207-213. McIsaac, D. I.; Geier, S. J.; Vogels, C. M.; Decken, A.; Westcott, S. A.* Inorg. Chim. Acta. 2006, 359, 2771-2779.

Anti-Cancer Compounds III

Novel organometallic palladium and platinum complexes as potential anticancer compounds.

Jean, S.; Cormier, K.; Patterson, A. E.; Vogels, C. M.; Decken, A.; Robichaud, G. A.;* Turcotte, S.;* Westcott, S. A.* Can. J. Chem. 2015, 93, 1140-1146. Patterson, A. E.; Miller, J. J.; Miles, B. A.; Stewart, E. L.; Melanson, J.-M. E. J.; Vogels, C. M.; Cockshutt, A. M.; Decken, A.; Morin Jr., P.; Westcott, S. A. Inorg Chim. Acta 2014, 415, 88-94.

Gallium & Iron Hydroxypyridinones

This is a relatively new project in our laboratory examining the use of readily prepared hydroxypyridinones derived from maltol (a natural food additive found in the bark of larch trees, in pine needles, and in roasted malt…mmm beer) and a primary amine. Hydroxypyridinones are used to treat iron-overload and we are testing the gallium complexes for their potential to act as antibiotics and anticancer agents.